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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and Development of Clarithromycin Dispersible Tablets

Author: AMAR CHAUDHARY, HEMANT MALIK
Abstract: ABSTRACT: H. pylori is a small, spiral, gram negative organism which colonizes on gastric mucosa of human stomach and produces a serious gastro duodenal disease—including peptic ulcers, gastric lymphoma and acute chronic gastritis. For complete eradication of H. pylori is to treat patient with one or more antibiotics. Clarithromycin is a macrolide, orally absorbed, broad spectrum antibiotic. It is widely used in a standard eradication treatment of gastric H. pylori infection combined with a second antibiotic and an acid-suppressing agent. It is practically insoluble in water. An attempt has been made to increase solubility of this model drug by formulating solid dispersion using super disintegrates. Five formulations in different concentrations of super disintegrate crospovidone, microcrystalline cellulose and Ac-Di-Sol were prepared by direct compression technique and evaluated for various pharmaceutical characteristics like hardness, friability, weight variation, drug content, disintegration, in vitro dissolution profiles and efficiency. Formulation D showed best dissolution profile and efficiency as compared to other formulations during evaluation which contains 20% crospovidone, 20% Ac-Di-Sol, 100% microcrystalline cellulose, 2.5% sodium saccharine, 1.5% vanillin, 2% talk and 5% magnesium stearate.
Keyword: Key words: Clarithromycin, Crospovidone, Ac-Di-Sol, Solid dispersion tablets.
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0.12
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