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METHOD OF MOLECULAR-GENETIC DIAGNOSTICS OF HEREDITARY OVARIAN CANCER
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| Author:
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T.A. BOGULYA
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| Abstract:
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The problem of diagnosis and treatment of ovarian neoplasms is one of the most difficult in gynecologic oncology. In
the majority of patients with malignant ovarian tumors, the disease is detected at later stages, so the results of the
treatment remain disappointing. Despite the high sensitivity of many modern methods of diagnostics, their specificity
is insufficient for the differentiation of benign and malignant processes in ovaries, which cannot provide effective
screening for early detection of malignant tumors. The study included the patients aged 19 to 69 with hereditary
ovarian cancer and excessive weight or obesity mostly from Moscow and Moscow Region who had two or more
relatives with I/II degree ovarian cancer and no breast cancer. The control group consisted of women suffering from
overweight or obesity, whose family members and they themselves had no ovarian cancer in past medical
history.DNA samples taken from 96 patients and their relatives were investigated, as well as from 40 individuals in the
control sample. Adipose tissue as microenvironment plays a key role in the initiation and progression of the tumor
growth because it supplies tumor cells with fatty acids and adipokines. The family of proteins which link fatty acids is a
group of small proteins, acting as intracellular fatty acid carriers. Fatty acid binding proteins,extracted from adipose
tissue, were represented by FABP4 and FABP5. They both play an important role in the metabolism of lipids and
overexpress in cases of many types of cancer, such as breast cancer, prostate cancer, colorectal cancer, and ovarian
cancer. Moreover, their expression is abnormal in peritumoral adipose tissue, while circulation levels increase during
the tumor grows.
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| Keyword:
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fatty acid binding proteins, hereditary ovarian cancer, molecular-genetic diagnostics, obesity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.041
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| Download:
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