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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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5 - Years Impact Factor

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Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

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Impact Factor: 1.3

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Impact Factor: 0.973

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Total Citation: 285

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How transcutaneous electrical nerve stimulation (TENS) improves fertility in healthy women, the role of estradiol hormone

Author: IHSAN AJEENA, NADA AL-HARIS, MOUSA M AL-ALLAK, ZAKI SLEIMAN, HUDA N AL-KEFAE
Abstract: In last few years, many studies have carried out to understand the effect of TENS technique on reproductive field and several mechanisms have proposed to explain how TENS might be beneficial.Among these are the impact on estradiol hormone (E2) secretion and size of ova,through TENS effects on Hypothalamic-Pituitary-Ovarian axis. It is suggest that normal E2level is very important inregulating behavioral and physiological events essential for successful procreation. This study aimed to test the usefulness of TENS in normalizing E2 level in women considering the impact of participants' age and body mass index (BMI) on the results. This is a prospective randomized controlled clinical trial including forty six healthy women within their child bearing age. For all the participants, E2 level and ova size are measured at day 13 of menstrual cycle before TENS application and at the same day of the next cycle after 6 session of TENS were applied. The results are classified according to the age and BMI of the participants. TENS significantly increases E2 leveland ova size. Subsequently, thesesincrease the rate of pregnancy bycontrolling the development and maintenance of female reproductive tissues. This is true as TENS normalizes dysfunctions of Hypothalamic-Pituitary- Ovarian axis,whichresult inreleasing of gonadotropin releasing hormone (GnRH) from the hypothalamus. Thisleads to release of luteinizing hormone (LH) and follicular stimulating hormone (FSH) from pituitary gland which controls ovulation by promote follicular growing. As the follicle grows, granulose cells divide and proliferate within the follicle that secret E2 and subsequently increasing itsserum level. In conclusion, there are beneficial effects of TENS to increase size of ova and serum E2 level and subsequently, the fertility in healthy women at their child bearing age.
Keyword: Transcutaneous electrical nerve stimulation (TENS), female fertility, ova size, Estradiol hormone.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.035
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477