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The Role of HSP72 in Patient with Graves ‘disease and Non-autoimmune Hyperthyroidism in AL-Najaf Province
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| Author:
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EMAN NADHAIF, MUHAMED ALI S. AL KABE, ISRAAKETABAL YASIRI, ZAYTOON A. ALKHAFAJI
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| Abstract:
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Graves ' disease (GD) is an autoimmune thyroid disease defined by the production of stimulating autoantibodies to
the thyroid-stimulating hormone receptor (TSHR) (TSAb) that induce a sustained state of hyperthyroidism in patients.
This study aimed to evaluate the role of Heat Shock Protein 72 "HSP72” in patients with Graves' disease in
comparison with other non-autoimmune hyperthyroidism in AL-Najaf province. A case control study included
patients with early diagnosis of thyrotoxicosis were randomly selected in endocrine center/Al Sadder Medical city.
Whole blood samples were collected from 60 patients and sent into thebiochemistry department of internal
Laboratory of AL-Sadder Medical City/ Najaf/Iraq, from the period between Sep. 2017 till Apr. 2018. Hyperthyroidism
patients were subdivided into two groups: Autoimmune hyperthyroidism "Graves' disease" patients group and Nonautoimmune
hyperthyroidism patients group, depending on Anti-TSHR Abs and Anti-TPO Abs. Healthy control group
of 40 people who had no history or clinical evidence of hyperthyroidism or any chronic disease. Patients with
hyperthyroidism under treatment and pregnant women were excluded from the study. The parameter studied in this
work was: Heat Shock Protein 72 "HSP72". Our study showed that significant difference (P=0.05) between Graves’
disease patients, non-autoimmune hyperthyroidism patients and healthy control groups (114.8279, 110.7479 and
67.7500, respectively). In anti-HSP72 antibody that has been detected in sera of Graves' disease patients. levels of antihsp72
antibodies demonstrated in GD patients had higher index than that of control subjects. However, the absence
of a correlation with disease severity or activity makes it unlikely that hsp72 antibodies play an important role in the
pathogenesis of GD.hsp72 antibody should be investigated thoroughly to correlate it along with the prognosis and
severity of GD.
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| Keyword:
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hsp72 antibody,autoimmune disease, Grave’s Disease.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.033
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| Download:
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