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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Determination of MTHFR-G17793A gene polymorphism in Iraqi morbidly obese population and correlated that with apolipoprotein-A5 in increased risk of cardio vascular disease

Author: FATIMAH ABED, HANAAADDAI ALI, OMIDRANAEI SIADAT, SAREH ARJMAND, FATANEH FATEMI
Abstract: In this paper, because the methylenetetrahdrofolate reductase (MTHFR) association with many disease, we to evaluate the apolipoprotein-A5 (Apo-A5) levels and association of the polymorphism with morbidly obesity on risk of cardiovascular disease (CVD), a case-control study of 74 healthy morbidly obese and 76 healthy non-obese was conducted in Iraqi populationthat matched in gender and age. Apolipoprotein-A5, is main lipoprotein composing triglycerides rich lipoprotein and involving the risk of heart disease.Therefore Apo-A5 plays important role in regulation of lipids in the body. Although there are adequate traditional factors for cardiovascular risk but knowledge of genetic factor risk is still incomplete. Different biochemical parameters were measurement and polymorphism was genotyped by polymerase chain reaction (PCR-RFLP). The mean ± standard error (SE) and T test were estimate for clinical parameter and odds ratio (OR) with 95% confidence interval added to chi squire estimated for genotype to assess the strength of association between genetic and other factors. The results shows that morbidly obese have higher levels in blood pressure, cholesterol (Ch), triglyceride (TG), very low density lipoprotein (VLDL-C) and low density lipoprotein (LDL-C) than non-obese. In other hand shows not significant differences between two groups in value of high density lipoprotein (HDL-C) but show lower level in Apo-A5 in morbidly obese than non-obese groups. The study revealed that MTHFR-G1793A has not significant relation in three type normal homozygous ,heterozygous and rare homozygous with obesity.
Keyword: Apolipoprotein-A5, morbidly obese, MTHFR-G1793A, cardiovascular disease (CVD).
DOI: https://doi.org/10.31838/ijpr/2019.11.02.032
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