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Determination of MTHFR-G17793A gene polymorphism in Iraqi morbidly obese population and correlated that with apolipoprotein-A5 in increased risk of cardio vascular disease
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| Author:
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FATIMAH ABED, HANAAADDAI ALI, OMIDRANAEI SIADAT, SAREH ARJMAND, FATANEH FATEMI
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| Abstract:
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In this paper, because the methylenetetrahdrofolate reductase (MTHFR) association with many disease, we to
evaluate the apolipoprotein-A5 (Apo-A5) levels and association of the polymorphism with morbidly obesity on risk of
cardiovascular disease (CVD), a case-control study of 74 healthy morbidly obese and 76 healthy non-obese was
conducted in Iraqi populationthat matched in gender and age. Apolipoprotein-A5, is main lipoprotein composing
triglycerides rich lipoprotein and involving the risk of heart disease.Therefore Apo-A5 plays important role in
regulation of lipids in the body. Although there are adequate traditional factors for cardiovascular risk but knowledge
of genetic factor risk is still incomplete. Different biochemical parameters were measurement and polymorphism was
genotyped by polymerase chain reaction (PCR-RFLP). The mean ± standard error (SE) and T test were estimate for
clinical parameter and odds ratio (OR) with 95% confidence interval added to chi squire estimated for genotype to
assess the strength of association between genetic and other factors. The results shows that morbidly obese have
higher levels in blood pressure, cholesterol (Ch), triglyceride (TG), very low density lipoprotein (VLDL-C) and low
density lipoprotein (LDL-C) than non-obese. In other hand shows not significant differences between two groups in
value of high density lipoprotein (HDL-C) but show lower level in Apo-A5 in morbidly obese than non-obese groups.
The study revealed that MTHFR-G1793A has not significant relation in three type normal homozygous ,heterozygous
and rare homozygous with obesity.
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| Keyword:
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Apolipoprotein-A5, morbidly obese, MTHFR-G1793A, cardiovascular disease (CVD).
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.032
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| Download:
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