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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Molecular Detection of Antimicrobial Resistance Genes in Urinary Tractional Infectious (UTI) patients In Babylon Site, Iraq

Author: ABBAS. GHALI.HAMED, ABBAS.K. AL-MANSOORI, MOHAMMED .TALIB. AL-TAMIMI
Abstract: Beta-Lactamase resistance among Enterobacteriaceae, especially in Escherich coli, is an emerging problem worldwide. The present study focused on determining prevalence of (blaCTX-M, and blaSHV-5genes coding Beta-Lactamase resistant in to the family Enterobacteriaceae via PCR technique. 30 clinical bacterial isolate were obtained from Babylon teaching hospital for identification UTI Nosocomial infection patients. E. coli was the most common bacterial strains from Beta-Lactamase isolates belonging to the family Enterobacteriaceae. The results of the present study indicated that prevalence of Beta-Lactamase resistant Escherich coli isolates was from patients (2 to 18 years) since that E. coli Beta-Lactamase genes were detected in some labs out of the 71.6 positive isolates. blaAMPC and bla TEM were significantly prevalence in all bacterial isolates compare with blaCTX-M and blaSH-5 at p = 0.05. The percentage of the prevalance of blaAMPC and bla TEM were 93.33 and 71.66respectively while the less percentage were observed in blaSHV-5 blaAMPC 20% and bla TEM 46.66%.Virulence factors were also examined between these genes and some other genes that were studied in the same laboratory by other group at the same university to inspect the possible relation between virulence genes and antimicrobial resistance in some pathogenic bacteria. Considering the fact that the presence of recognized infective determinants among clinical isolates may promote the emergence of infections and persistence of pathogens. The results of virulence gene indicated that biofilm gene was the most prevalence gene, where appeared in 95% of bacterial isolates following by iss gene 86.6% and fimH gene 85%.Current study showed a strong significant correlation between virulence and antibiotic resistance profile , where the statistical analysis revealed that the person correlation was 0.957 between virulence and antibiotic s determinants. Hence the establishing of the correlation between resistance and virulence profile could provide input for the clinical evolution and of different bacterial infection rates recurrence.
Keyword: Beta-Lactamase, blaCTX-M, blaSHV-5
DOI: https://doi.org/10.31838/ijpr/2019.11.02.031
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477