IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Computational approach for siRNA Based RNA Interference of ATP synthase subunit alpha coding gene of different strains of Mycobacterium tuberculosis

Author: NEEMA TUFCHI, KUMUD PANT, ASHISH THAPLIYAL
Abstract: Tuberculosis is a major health concern and around one third of the population is infected globally. The causative agent Mycobacterium tuberculosis is becoming resistant towards the available drug gradually and worsening the cases to multiple drug resistance and extensive drug resistance. Besides developing resistance towards the drugs, the bacterium is also clever enough that by infecting the host it modifies the host protein at cellular as well as at tissue level. So, there is an extensive need to develop a therapeutic that can fight with tuberculosis. RNA interference is well known technique for the silencing of the substantial genes in numerous biological systems. In the current study we have performed the computational approach for designing possible siRNA molecules. Various tools like sequence similarity check, target alignment, secondary structure prediction and RNA interaction evaluation was used to design siRNA for the target. The siRNA and chemically modified si-RNA (cm-siRNA) for gene silencing of various strains of Mycobacterium tuberculosis were rationally designed and authenticated by all the rules required for synthesis of siRNA through computational method. ?Gbinding of the target and its predicted siRNA was calculated to be -29.26 kcal/mol and between target and cm-siRNA was -27.91 kcal/mol. The designed siRNA might lead to knockdown the pathogenic activity of the bacterium Mycobacterium tuberculosis.
Keyword: Tuberculosis, Mycobacterium tuberculosis, RNA interference, siRNA, cm-siRNA
DOI: https://doi.org/10.31838/ijpr/2019.11.02.008
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477