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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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SYNTHESIS AND CHARACTERIZATION OF ISONIAZID INCORPORATED THIOFIBRATES

Author: NIRANJAN SAND
Abstract: In the present study two novel thiofibrates bearing 1, 3, 4-oxadizole and 1,2,4-triazole are prepared from isonicotinic acid hydrazide (1). The compound (1) is on reaction with carbon disulfide in the presence of potassium hydroxide gave 5-(pyridin-4-yl)-1,3,4-oxadiazol-2-thiol (2). This on treating with ethyl-2-bromo isobutyrate in presence of anhydrous potassium carbonate in DMF yielded compound ethyl 2-methyl-2-[{5-(pyridin-4-yl)-1,3,4-oxadiazol-2- yl}sulfanyl] propanoate(3). Compound 1 on further reaction with phenyl isothiocyanate in presence of sodium hydroxide forms 4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-thiol) (4). This when treated with ethyl-2-bromo isobutyrate under the similar conditions in obtaining compound (3) gave ethyl-2-methyl-2-{[4-phenyl-5-(pyridin-4-yl)- 4H-1,2,4-triazol-3-yl] sulfanylpropanoate (5). The progress of the reactions were monitored by TLC. The structures of the
Keyword: Isonicotinic acid hydrazide, thiofibrate, ethyl-2-bromo isobutyrate, phenyl iso thiocyanate, carbon disulfide.
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