|
Anti-venom activity of ethanolic extract of leaves of Ampelocissusaraneosa
|
|
| Author:
|
SELLAMUTHU VENKATESH, ANGAPPANSHEELA
|
| Abstract:
|
The objective for the current study was to investigate the anti-venom activity of leaves of
Ampelocissusaraneosaextract. The air dried powdered leaves of Ampelocissusaraneosa was extracted with ethanol by
using the Soxhlet extractor. The prepared extract was subjected to acute toxicity study and in-vitroprocoagulant
activitiesand in-vivo neutralization anti-venom activity and effect of bleeding time in mice. Acute toxicity study was
carried out according to the OECD guidelines 425. The in-vivo neutralization anti-venom activity of extract was
performed on Swiss Albino mice. The results of acute toxicity study revealed that the Ampelocissusaraneosaextract
was safe till 2000 mg/kg body weight. The 200 and 400 mg/kg of ethanolic extract of leaves of
Ampelocissusaraneosasignificantly neutralizes the lethality (up to 2 folds) induced by the Najanajavenom in both invitro
and in-vivo anti-venom activities and exert potent anti-venom activity both in-vitro and in-vivo.
|
| Keyword:
|
Ampelocissusaraneosa; leaves; ethanolic extract; acute toxicity; anti-venom activity.
|
| EOI:
|
-
|
| DOI:
|
-
|
| Download:
|
Request For Article
|
|
|