IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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January - March 6 [1] 2014

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Ibudilastand Octreotide both Ameliorate Acute Pancreatitis via Down-Regulation of the Inflammatory Cytokines and Toll-Like Receptor 4 Expression

Author: ALAA GHAZI, SAMEER H ABOOD, HASSAN ALAKOULI, FATIMA GHIZAL, ABDI AFROZ, NAJAH HADI
Abstract: Acute pancreatitis (AP) is severe inflammationof the pancreas that can be of two major types: mild AP (MAP) and severe AP (SAP).To study the therapeutic effect of Ibudilast in comparison with older drug, Octreotide, in the rat model of AP.A total of 48 male rats were divided into 8groupswith each group consisting of 6 rats. Acute Pancreatitis was induced by L-arginine model which has a high reproducibility. Octreotide and Ibudilast were administered individually and in combinationat 0, 8 and 16 hours after induction. After 24 hours of treatment, each rat was weighed and blood samples were withdrawn for ELISA test and for Toll-like receptor 4 (TLR4) expressionanalysis, and then the pancreas was extractedto obtainthe pancreatic weight to the totalbody weight(PW/TBW) ratio.
Keyword: Ibudilast, Octreotide, Acute Pancreatitis, Inflammatory Cytokines, Toll-Like Receptor
DOI: https://doi.org/10.31838/ijpr/2019.11.02.024
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477