IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Investigation of USPION genotoxicity on Cytokinesis Blocked Micronuclei

Author: MRSISHRAQABBOODI FADHIL
Abstract: Micronuclei (Mn) are structures that arise from acentric chromosome fragments or complete chromosomes that failed to stick to mitotic spindle during cytokinesis and are rejected from the daughter nuclei into the cytoplasm. In this experiment, we tested human lymphoblastoid-B cells were treated with different ultrafine superparamagnetic iron oxide nanoparticles (USPION) and performing the micronucleus assay from genotoxic and cytotoxic effects by measuring the frequency of binuclear Bn and Mn cells in a cell population analysed. The results showed that treating with 50nm USPION was more effective than 600nm nanoparticles as it presented significant decline in %BN curve with a sudden increase for %Mn/BN curve. The examined human cells appeared some resistance to the external changes, at the first time, and then looked to be exhausted to face the additional doses.
Keyword: Micronuclie, USPION, Genotoxic and cytotoxic effects, human lymphoblastoid Bcells.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.019
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477