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Sensitive Spectrophotometric Determination of Doxycycline in Pure and Dosage Forms using p-Bromanil
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| Author:
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NAHLA. ALASSAF, FAEZA H. ZANKANAH
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| Abstract:
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A simple, precise, and sensitive spectrophotometric method has been established for the analysis of doxycycline. The
method includes direct charge transfer complexation of doxycycline withp-Bromanil in acetonitrileto form a colored
complex. The intensely colored product formed was quantified based on the absorption band at 377 nm under
optimum condition. Beer’s law is obeyed in the concentration range of 1–50 µg.mL-1 with molar absorptivity of
1.5725x104 L.mol-1.cm-1, Sandell's sensitivity index (0.0283) µg.cm-2, detection limit of 0.1064 µg.mL-1,
quantification limit 0.3224 µg.mL-1 and association constant of the formed complex (0.75x103). The developed
method could find application in routine quality control of doxycycline and has been successfully applied for the
determination of the cited drug in commercial formulations (capsules) with good accuracy and precision and without
a detectable interference from common excipients.
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| Keyword:
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spectrophotometric,cited drug,doxycycline
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.016
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| Download:
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