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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Sensitive Spectrophotometric Determination of Doxycycline in Pure and Dosage Forms using p-Bromanil

Author: NAHLA. ALASSAF, FAEZA H. ZANKANAH
Abstract: A simple, precise, and sensitive spectrophotometric method has been established for the analysis of doxycycline. The method includes direct charge transfer complexation of doxycycline withp-Bromanil in acetonitrileto form a colored complex. The intensely colored product formed was quantified based on the absorption band at 377 nm under optimum condition. Beer’s law is obeyed in the concentration range of 1–50 µg.mL-1 with molar absorptivity of 1.5725x104 L.mol-1.cm-1, Sandell's sensitivity index (0.0283) µg.cm-2, detection limit of 0.1064 µg.mL-1, quantification limit 0.3224 µg.mL-1 and association constant of the formed complex (0.75x103). The developed method could find application in routine quality control of doxycycline and has been successfully applied for the determination of the cited drug in commercial formulations (capsules) with good accuracy and precision and without a detectable interference from common excipients.
Keyword: spectrophotometric,cited drug,doxycycline
DOI: https://doi.org/10.31838/ijpr/2019.11.02.016
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