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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Role of phitofert in sperm functions and biochemical parameters of indomethacin-treated rats

Author: NAHLA M., AL-SHAHERY
Abstract: The present study aimed to investigate the underlying mechanism of reduction fertility that induced by long-term treatment with indomethacin, also to test the capability of phitofert product to modulate of indomethacin treated infertility. Subsequently sixty adult male rats were divided into 4 groups (15 rats each) as follows: Group1: rats were orally administrated with physiological saline (0.9% NaCl) for 60 consecutive days (Control). Group2: rats were orally administrated with 3 mg.Kg-1 b.w. of indomethacin for 60 consecutive days. Groups3:rats were orally administrated with 3 mg.Kg-1 b.w. of indomethacin gathered with physiological saline for 60 consecutive days. Group4: rats were orally administrated with 3 mg.Kg-1 b.w. of indomethacin gathered with 7 mg.Kg-1 b.w. of phitofert for 60 consecutive days. Indomethacin-treated rats (Groups 2 and 3) in comparison with control (Group 1) showed a significant (p=0.05) decrement in the testicular and epididymal enzymatic activity LDH-C4, ACP and the testicular steroidogenic enzyme 17ß-HSD3. Also, these groups had significant (p=0.01) decrease in the testicular and serum testosterone and cholesterol levels. Besides, the oxidative status were noticed in the testicular and epididymal of treated group 2 and 3 representing by a significant (p=0.01) increment in the MDA levels and a significant (p=0.01) lower in the catalase activity compared to control (Group 1). Additionally, it was noticed a significant (p=0.01) decrease in the all sperm parameters. Our data have shown the ability of phitoferttreatment in recovery all above passive variables.
Keyword: DH-C4,3 mg.Kg-1 b.w.,(p=0.01)
DOI: https://doi.org/10.31838/ijpr/2019.11.02.013
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477