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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Novel Particle Technology Used To Increase Dissolution Rate Of Poorly Water Soluble Drugs

Author: PRAKRUTI AMIN, MS. PRAKRUTI M.AMIN P*, DR. DHANANJAY M.PATIL, MS. PRAGATI M.AMIN
Abstract: An increasing problem for the pharmaceutical development is the larges number of poorly water soluble drug emerging from drug discovery that have an aqueous solubility lower than 0.1 mg/ml. Currently 40% of the drug in the development pipeline and 70% of new chemical entity coming from organic synthesis facing the problem of poor water solubility which affect oral bioavailability and over all pharmacology of drug. This review present novel particle technology to modify physicochemical and micromeritics properties of poorly soluble drug and hence solubility, dissolution and bioavailability of drugs.Problemetic poor water soluble compounds need to be formulated with new techniques in order to save time and resources during the formulation effort. This review highlights the novel particle technology that improves dissolution rate of poorly aqueous soluble drug and hence in vivo bioavailability.
Keyword: Solubility, Dissolution Rate, Bioavailability, Particle Technology
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0.12
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