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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Ondansetron on Post-Anesthesia Delirium in Sevoflurane-Anesthetized Children Undergoing Eye Surgery in Farabi Hospital in 2015

Author: ALIREZA TAKZARE, HOSSEIN SADROSSADAT, MEHDI SANATKAR, SHAHRAM ROUSTAIE, MEHRDAD GOUDARZI
Abstract: Introduction and Objective: Emergence delirium is a common side effect in children undergoing general anesthesia, which can lead to self-harm and parental dissatisfaction due to agitation. The prevalence of emergence delirium after general anesthesia with sevoflurane is estimated to be 18-80%. The present study aimed to investigate the effect of ondansetron on post-anesthesia delirium in sevoflurane-anesthetized children undergoing strabismus surgery. Methodology: In this study, 60 children of 2-12 years of age with ASA one and two who were candidates for elective strabismus surgery, were randomly divided into two groups after obtaining their parents’ consent. After induction of anesthesia, one group received 100 mg/kg ondansetron and the other group received saline. Anesthesia continued with sevoflurane and patients were evaluated after the surgery in the recovery room using a data collection form. Findings: The mean PAED score in the ondansetron and placebo groups was 10.8 and 10.9, respectively (p=0.9), which indicates the ineffectiveness of this drug on post-anesthesia delirium. The incidence of vomiting was 33% in the placebo group and 13% in the ondansetron group (p=0.05). Conclusion: According to the results obtained in this study, ondansetron had no direct effect on the reduction of delirium intensity in children anesthetized with sevoflurane. However, given the significant reducing effect of ondansetron on post-anesthesia vomiting, its use seems reasonable.
Keyword: delirium, anesthesia, children, ondansetron
DOI: https://doi.org/10.31838/ijpr/2019.11.01.134
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