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Effect of Ondansetron on Post-Anesthesia Delirium in Sevoflurane-Anesthetized Children Undergoing Eye Surgery in Farabi Hospital in 2015
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| Author:
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ALIREZA TAKZARE, HOSSEIN SADROSSADAT, MEHDI SANATKAR, SHAHRAM ROUSTAIE, MEHRDAD GOUDARZI
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| Abstract:
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Introduction and Objective: Emergence delirium is a common side effect in children undergoing general anesthesia,
which can lead to self-harm and parental dissatisfaction due to agitation. The prevalence of emergence delirium after
general anesthesia with sevoflurane is estimated to be 18-80%. The present study aimed to investigate the effect of
ondansetron on post-anesthesia delirium in sevoflurane-anesthetized children undergoing strabismus surgery.
Methodology: In this study, 60 children of 2-12 years of age with ASA one and two who were candidates for elective
strabismus surgery, were randomly divided into two groups after obtaining their parents’ consent. After induction of
anesthesia, one group received 100 mg/kg ondansetron and the other group received saline. Anesthesia continued
with sevoflurane and patients were evaluated after the surgery in the recovery room using a data collection form.
Findings: The mean PAED score in the ondansetron and placebo groups was 10.8 and 10.9, respectively (p=0.9), which
indicates the ineffectiveness of this drug on post-anesthesia delirium. The incidence of vomiting was 33% in the
placebo group and 13% in the ondansetron group (p=0.05).
Conclusion: According to the results obtained in this study, ondansetron had no direct effect on the reduction of
delirium intensity in children anesthetized with sevoflurane. However, given the significant reducing effect of
ondansetron on post-anesthesia vomiting, its use seems reasonable.
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| Keyword:
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delirium, anesthesia, children, ondansetron
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.134
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| Download:
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