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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Testing on the Effectiveness of Anti Acne Gel (Acne vulgaris) Mild and Moderate Degree Acne from Ethanol Extract of Galanga (Kaemferia galanga L.) in Students at Miftahus Salam Boarding School in Banyumas

Author: YENNI BAHAR, YENNI BAHAR, BERNA ELYA, MAHDI JUFRI
Abstract: Acne is an aesthetic skin disorder which generally occurs in adolescents, with a clinical manifiestation of comedones, papules, pustules, and nodules. The aim of this research was to know the antibacterial activity of Kaempferia galanga L rhizome against the P.acne bacteria, to know the physical stability of the Kaempferia galanga L extract gel, its safety, and its effectiveness as an anti acne gel for the treatment of mild to moderate degree of acne. Extraction was done by maceration using 96% ethanol. Antibacterial activity testing was observed at concentrations of 0.75; 1.25; 1.75; 2.25%. The gel with a concentration of 0.75% had an inhibition zone of 11.5 mm in Brucella medium. Based on the physical stability of the Kaempferia galanga L extract gel, the gel had a good physical stability profile. Safety trials which was evaluated on 12 students found no irritation nor allergy. Treament using the Kaempferia galanga L extract gel was given to 30 individuals, and treatment using clindamycin was given to the other 30 individuals as the positive control. After 3 weeks of evaluation, Kaempferia galanga L extract gel gave a significant (<0.01) improvemet on mild as well as moderate acne.
Keyword: galanga rhizome, acne lession, P.acne
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0.12
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