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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Study of LD50 and chronic toxicity of suspension of Silver nanoparticles size 50 nm in laboratory rats

Author: NINO CHICHIVEISHVILI, TEIMURAZ TAVKHELIDZE, SALOME KHUBULAVA, GIORGI PITCHKHAIA, JENARA KRISTESASHVILI, DAVIT KACADZE
Abstract: Antibiotic era is coming to the end, becouse of the wrong selecting of antibiotics and combination therapy and the mutation skills of bacteria. In recent years, the use of nanosilver particles for therapeutic purposes has become more relevant. These particles have an antibacterial effect and a fairly good effect on local inflammatory processes. We made suspension of silver nanoparticles size 50 nm by the physic method and introduced into laboratory rats. Our studies demonstrates that argentium nano-particles can be administered in physical (non-chemical) pathways. It does not have LD50, however, its consumption with high doses for prolonged period of time leads to histomorphological changes in healthy tissues.
Keyword: silver nanoparticles, Drug toxicity.a
DOI: https://doi.org/10.31838/ijpr/2019.11.01.121
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