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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antidiarrheal Activity of Methanolic Extract of Moringa oleifera Lam Roots in Experimental Animal Models

Author: UPLOADED BY-ADMIN, MAHESH G. SARALAYA, PARAS PATEL, MANISH PATEL, SAMRESH PAL ROY, ASISH.N.PATEL
Abstract: Among medicinal plants, Moringa oleifera Lam. has been recommended for several disorders in folk medicine. Indian Materia Medica describes the use of roots of Moringa oleifera Lam in the treatment of a number of ailments, including asthma, gout, lumbago, rheumatism, enlarged spleen or liver, etc. Nevertheless, no pharmacological studies of Moringa oleifera Lam root have thus far evaluated for its anti diarrheal activity. Thus the purpose of the present study is to evaluate scientifically the effect of hydroalcoholic (50:50) extract of root of Moringa oleifera Lam against castor oil induced diarrhea models in rats. The parameters used for the evaluations are the decrease in severity and frequency in diarrheas caused due to castor oil, futher to understand the probable mechanism of its anti-diarrhoeal activity, its effect was evaluated on intestinal transit, castor oil induced intestinal fluid accumulation (enteropooling) and electrolyte concentration in the small intestinal fluid. The methanolic root extract of Moringa oleifera Lam 200 (p<0.01)and 400 mg/kg (p<0.001)produced a significant reduction in the severity and frequency of diarrhea, intestinal fluid accumulation, the volume of intestinal content and intestinal transit compared to normal saline control group, dose dependently more than atropine( 3mg/kg i.p). This signifies the usefulness of this model and the clinical effect of the extract. Moringa oleifera Lam root extract may be useful in a wide range of diarrheal states due to both disorders of transit e.g.functional diarrhoeas, radiation diarrhea or due to abnormal secretory mechanisms like in cholera or E.coli entero-toxin induced diarrhea. Further studies are necessary for chemical characterization of the active principles and more extensive biological evaluations.
Keyword: Moringa oleifera, intestinal fluid accumulation, volume of intestinal content, intestinal transit, radiation diarrhea.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.100
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