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Synthesis, Spectral characterization, Thermal analysis, Antimicrobial and Antitumor Properties of new azo ligand with some of its Transition Metal complexes
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| Author:
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NADA HUSSEIN, RAHEEM T. MAHDI
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| Abstract:
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Complexes of Palladium (II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) with (E)-8-((4,5-bis(4-
methoxyphenyl)-1H-imidazol-2-yl)diazenyl) quinoline have been prepared and characterized by elemental analysis
(C.H.N.S) ,magnetic susceptibility measurements., conductance measurements, UV-Vis spectra, FT-IR, ,1H-NMR
,mass spectra, FESEM, TGA, and XRD data . The analytical data show that the mole ratio [M:L] was [1:2] for Co(II),
Ni(II), Cu(II), Zn(II) and Cd(II) metal ion and [1:1] for Pd(II) metal ion. It was found that the azo dye ligand behaves a
tridentate and coordinates to the metal ion via nitrogen atom of azo group of heterocyclic imidazole ring , nitrogen
atom of azo group and nitrogen atom of quinolone ring. octahedral geometry is suggested for the Co(II), Ni(II),
Cu(II), Zn(II) and Cd(II) complexes and square planar geometry for the Pd(II) complex. The ligand and its metal
complexes have been screened for their antibacterial activity against gram positive streptococcus ,Staphylococcus
aureus and gram negative bacteria Escherichia coli , antifungal action against Candida. In this investigation, the
cytotoxicity of the ligand and Ni(II) complex was screened for in vitro ; antitumor movement against human breast
cancer MCF-7 utilizing MTT examine . The tried of the prepared ligand and its Ni(II)complex demonstrated anticancer
movement with IC50 values indicated cytotoxicity against malignant growth cell line with IC50 = 141.0 µg/ml ; WRI-
68 IC50 = 334.4 µg/ml , while Ni(II)- complex demonstrated specific cytotoxicity against disease cell line with IC50
=149.1 µg/ml; WRI-68 IC50 = ~5198 µg/ml. The outcomes demonstrated that this sort of compounds plays an
important role in the rate of hindrance of the development of cells of destructive and normal lines and showed
without a doubt the likelihood of utilizing them as antitumor medications against breast cancer
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| Keyword:
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Synthesis, Imidazolylazo Dye, Biological Activity.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.084
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| Download:
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