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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Spectral characterization, Thermal analysis, Antimicrobial and Antitumor Properties of new azo ligand with some of its Transition Metal complexes

Author: NADA HUSSEIN, RAHEEM T. MAHDI
Abstract: Complexes of Palladium (II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) with (E)-8-((4,5-bis(4- methoxyphenyl)-1H-imidazol-2-yl)diazenyl) quinoline have been prepared and characterized by elemental analysis (C.H.N.S) ,magnetic susceptibility measurements., conductance measurements, UV-Vis spectra, FT-IR, ,1H-NMR ,mass spectra, FESEM, TGA, and XRD data . The analytical data show that the mole ratio [M:L] was [1:2] for Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ion and [1:1] for Pd(II) metal ion. It was found that the azo dye ligand behaves a tridentate and coordinates to the metal ion via nitrogen atom of azo group of heterocyclic imidazole ring , nitrogen atom of azo group and nitrogen atom of quinolone ring. octahedral geometry is suggested for the Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes and square planar geometry for the Pd(II) complex. The ligand and its metal complexes have been screened for their antibacterial activity against gram positive streptococcus ,Staphylococcus aureus and gram negative bacteria Escherichia coli , antifungal action against Candida. In this investigation, the cytotoxicity of the ligand and Ni(II) complex was screened for in vitro ; antitumor movement against human breast cancer MCF-7 utilizing MTT examine . The tried of the prepared ligand and its Ni(II)complex demonstrated anticancer movement with IC50 values indicated cytotoxicity against malignant growth cell line with IC50 = 141.0 µg/ml ; WRI- 68 IC50 = 334.4 µg/ml , while Ni(II)- complex demonstrated specific cytotoxicity against disease cell line with IC50 =149.1 µg/ml; WRI-68 IC50 = ~5198 µg/ml. The outcomes demonstrated that this sort of compounds plays an important role in the rate of hindrance of the development of cells of destructive and normal lines and showed without a doubt the likelihood of utilizing them as antitumor medications against breast cancer
Keyword: Synthesis, Imidazolylazo Dye, Biological Activity.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.084
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