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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and biological activity evaluation of some new pyrazole derivatives

Author: REEM NAJM
Abstract: Mixture of p - acetophenoneand sodium hydroxide were added to ethanol followed by vanillin addition. This reactions yield, 3-(4-hydroxy-3-methoxyphenyl)-1-(4-nitrophenyl) prop-2-en-1-one, 1-(4-chlorophenyl)-3-(4-hydroxy-3- methoxyphenyl)prop-2-en-1-one, 1-(4-bromophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one, and 3-(4- hydroxy-3-methoxyphenyl)-1-(4-iodophenyl)prop-2-en-1-one. Serial other reactions were performed to synthesized twelve other compounds which were identified by melting point, IR spectrometer, and two of them were by 1H- N.M. R spectra. Some of the prepared compounds were evaluated for antibacterial activity which showed promising effect as antibiotics.
Keyword: Pyrazole, Sulfonamide, Chalcones, Antibacterial, Chemicals, P – Acetophenone.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.083
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