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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Features of Cellularand Humoral Immunore activity in Patients with Stable Angina and their Role in the Progression of Athrosclerotic Lesions

Author: VASILENKO V.S., AVDEEVA M.V., SHCHEGLOVA L.V, SHCHEGLOV D.S
Abstract: The purpose of the research was to examine the relationship between cellular and humoral immunoreactivity and the severity of atherosclerotic lesions of coronary arteries in patients with stable angina. We examined 68 patients with stable angina (mean age 60.2±10.3 years). The patients underwent coronary angiography in addition to numbers of immunological studies including the determination of the levels of circulating immune complexes, the leukocyte migration-inhibitory index (LMI) in presence of various antigens, the concentration of myocardial antigens in the blood as well as antibodies to them. We established a direct correlation between the level of circulating immune complexes and the development of hemodynamically significant coronary stenosis (r=0.32; p<0.05), as well as their amount (r=0.28; p<0.05) and the length of stenosis (r=0.32; p<0.05). We also found a correlation between the level of circulating immune complexes and the degree of stenosis of particular segments of coronary arteries (r=0.36?0.26; p<0.05). The titer of myocardial antigens associated with the total number of coronary occlusions (r=0.51; p<0.05), the number of hemodynamically significant stenosis (r=0.58; p<0.05) and the degree of coronary stenosis (r=0.57?0.46; p<0.05). The number of occlusions of the lumen of coronary arteries statistically significantly associated with the leukocyte migration-inhibitory index (LMI) stimulated by phytohemagglutinin(r=0.41; p<0.05). The study showed that cellular and humoral immunoreactivity are involved in the pathogenetic mechanisms of progression of atherosclerotic lesions of the coronary arteries. This should be considered when developing new technologies for treating cardiovascular diseases.
Keyword: atherosclerosis, humoral and cellular immunoreactivity, cardiovascular disease, coronary heart disease, multifocal atherosclerosis.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.078
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