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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Synthesis of Trehalose 4’,6’- Diesters and 2,3,2’,3’- tetra esters

Author: RWOA’A HAMEED
Abstract: Glycolipids (trehalose-6,6‘-dimycolates) found associated with the cell walls of mycobacteria as very complex mixtures. Cord factors are very strong signalling agents in the immune system. Synthetic analogues should be useful for diagnosis and treatment of TB, asthma, allergies and other immune system diseases. Trehalose dimycolate (TDM) is a molecule produced by Mycobacterium tuberculosis (Mb) and other mycobacteria. Trehalose monomycolate (TMM) is precursor of TDM, and is involved in providing mycolic acid to the cell wall arabinogalactan in order to form m-AGP complex. In this report, have been describe the synthesis ofregioselective monoacylation, by the protection of the a,a’-D-trehalose in the position of 4,6, 4’,6’ Di-O-benzylidene and 4’,6’-O-benzylidene by changing the equivalents and then are coupled different fatty acids with protected trehalose to get tetraesters and diester. The final step was deprotection trehalose in order to get the final results,have got synthesis six tetraesters and three diester of a,a’-Dtrehalose.. The synthesis of these compounds sets the stage for future biochemical studies to identify mycobacterium tuberculosis.
Keyword: TMM, TDM, Synthesis, Diesters, Tetra esters
DOI: https://doi.org/10.31838/ijpr/2019.11.01.068
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477