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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effects of Lipidum sativum against oxidative stress induced by mercuricchloride; study biochemical in liver function parameters and histopathological study.

Author: , , DUNYA KHALAF HAMAD AND ALIA H. ALI*
Abstract: 60 Swiss male rats weighing (175-325g) were used for the current study.The animals were allocated into 5 groups; the control group (C), mercuric chloride group (M), third, fourth and fifth groups were represented the treatment groups (T1, T2 & T3), each group was divided into two subgroups (21 and 42 days. The blood samples collection by heart puncture for serum AST, ALT, ALPand MDAand samples of liver for histopathological study. Lepidium sativum extract seed was prepared in doses of 25, 50.100 mg/kg.Results showed a significant increase in serumAST, ALT, ALP and MDAafter 21 and 42 days in group (M) in compared to control and significant decrease in serum AST, ALT, ALP and MDA in groups T1, T2 and T3 respectively that received Lipidum sativum extract Seeds in doses 100, 50, 25 mg/kg as compared with Mercury chloride group. In comparing AST between periods of 21 and 42 days after treatment showed significant difference in the second group (M) and T1.In comparing of serum ALP between periods of 21 & 42 days showed significant difference between groups (M) and T2.
Keyword: Lipidum sativum, histological, biochemical, mercuric chloride.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.066
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