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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis,characterization and Toxicological study for some new Compoundsderivedfrom(2E)-1,2- diphenyl-2-(phenylimino)ethan-1-one mercuric chloride and amino acidsin Musmusculusmice

Author: JAMAL HARBI.AL-SAADIAND , NUHAHUSSEIN.AL-SAADAWY
Abstract: (2E)-1,2-diphenyl-2-(phenylimino)ethan-1-one mercuricchloride Prepared from reacting between(Benzil andP-amino phenyl mercury chlorid) with1:1 mole ratio then product (2-{(E)-[(2E)-1,2-diphenyl-2- (phenylimino)ethylidene]amino}propanoicacid mercuricchloride) and(2-{(E)-(2E)-1,2-Diphenyl-2-phenyliminoethylideneamino)- 3-(1H-indol-3-yl)-propionic acid mercricchloride) ,reacted with amino acids such asalanin and troptophan with also 1:1 molar ratio.all prepared compounds was agreement with mass spectroscopy ,1HNMR, FT-IR Resuits.Toxicity studies carried in Musmusculusmice .The LD50 Values measurement by karber method, using different compounds dose (10 ,20 ,50 ,100 and 150)mg/kg BW ,were injected (IP) to the varionsgroups of mice ,LD50 of N1 was (102.5) and LD50 of N2 was (104.17) .
Keyword: OrganomercuryCompounsd,amino acids ,LD50
DOI: https://doi.org/10.31838/ijpr/2019.11.01.063
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