IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
PIPPHARMACON & IJPR 2018

PIPPHARMACON & IJPR 2018

Click to download
 

Article Detail

Label
Label
Role of NMDA receptor autoimmunity induced by food protein containing vaccines, in the etiology of autism, type 1 diabetes, neuropsychiatric and neurodegenerative disorders

Author: VINU ARUMUGHAM, MAXIM V. TRUSHIN
Abstract: Vaccines contain numerous animal and plant proteins (soy, peanut, sesame, maize, wheat, etc.). Vaccine excipients are derived from plant or animal sources. The mechanism of animal protein induced autoimmunity was previously described. Following a report associating maternal gluten intake to type 1 diabetes in the offspring, plant proteins were investigated. The Pandemrix vaccine induced narcolepsy due to molecular mimicry between a H1N1 nucleoprotein peptide in the vaccine and the human hypocretin receptor 2. The BLASTP match score for this peptide was used as a baseline. BLASTP showed strong sequence alignment between gliadin, a wheat protein, and the human ionotropic N-methyl-D-aspartate receptor (NMDAR). Analyzing further, strong sequence alignment was found between soy, peanut, sesame, maize, wheat and human glutamate receptors (GR), both ionotropic and metabotropic. There are reports of boosted wheat allergy and de novo synthesis of NMDAR antibodies following immunization. Once immunized with plant derived antigens, antibody levels will be increased by dietary exposure to these antigens. GR are expressed in the brain, heart, pancreas and the T cells of the immune system. Vaccine induced GR antibodies (GRA) disrupt or destroy GR thus precipitating numerous disorders. This explains the epidemic of food intolerances and food associated immune mediated disorders.Intestinal barrier disruption has been proposed as a cause for food associated autoimmune disorders. However, intestinal barrier disruption may itself be the result of GRA. GRA also disrupt the blood-brain barrier. This allows other anti-brain antibodies access to their targets. Vaccine-induced GRA can therefore explain a wide variety of disorders including autism, type 1 diabetes, attention deficit hyperactivity, epilepsy, schizophrenia, autoimmune encephalitis, Huntington’s, Parkinson’s, dementia, cancer and allergies.The ultimate solution is to immediately remove all non-target proteins from all vaccines.
Keyword: NMDAR, BLASTP, Vaccine-induced GRA
DOI: https://doi.org/10.31838/ijpr/2019.11.01.056
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
AICTE INTERNATIONAL CONFERENCE

AICTE Sponsored International Conference on Challenges, Opportunities and Newer Directions of Pharmacovigilance and Clinical Research in India

Download Brochure


For More Detail Visit www.pippharmacon.org
News & Events
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus
Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477