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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Anti-carcinogenic and cytotoxic effect of Carthamus oxycantha Safflower seed oil extract on Hela cell lines

Author: MUHAMMAD AL-SARHAN, LAITH MOHAMMED JAWAD AL-SHAMAA
Abstract: The current study investigates theeffect of plant abstract of Wild Safflower(Carthamasoxycantha) on Hela cell (cancer cell) that thought it works as anticancer drugs. Thesamples of theCarthamasoxycanthaare taken from thewest desert of Iraq while Hela cell supply by Iraqi Biochemistry company.Carthamasoxycanthauses asoily and aqueous extraction,anditsuses in many of different concentrations (eight concentrations) (7.81, 15.62, 31.25, 62.5, 125, 250, 500, 1000) µg /ml for each extract, and for 24,48, and 72 hours of exposure time. The final results show a gradually cellular toxic effect of extracts on Hela cell lines growth. Also, there are some differences in the effect of these extracts based on the extracts concentration and the time. The cytotoxic effect of the extracts kills 50% of cells (CC50) for each extract.Furthermore, we found the aqueous extract most potent cytotoxic extracts on Hela cell than oily extract. HeLa cells were the most sensitive to high concentrations, whatever the concentration increase; it will inhibitthe Hela cell more. Active compounds such as Triterpene concreted in flower, oleic acidandlinoleic acidhaveantitumor activity. As concluding, Carthamasoxycanthaextracts (aqueous or oily) have a great role in inhibition of cancer growth.
Keyword: The plant abstract, Carthamasoxycantha, Hela cell line.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.047
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