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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Inhibitory Efficiency of Flavonoid Extract of Black Mustard Seeds (Brassica nigra) and cold aqueous extract of Euphorbia prostrata L. on growth of Staphylococcus aureusinvitro and invivo

Author: HANAN NOURI
Abstract: The aim of this study is to evaluate the antibacterial activity for flavonoids extract for Brassica nigra and cold equeous extract for Euphorbia prostrata plants on growth of Staphylococcus aureus in vitro and in vivo. Six bacterial species were isolated and identified from different conditional cases like enteric infection, diarrhea and skin abses. These are Staphylococcus aureus (36.52%), Escherichia coli ,(44.34%), Bacillus cereus (4.34%), Klebsiellapneumoniae (6.08%), Pseudomonas aeruginosa (15.65%) and Proteus mirabilis (2.60%). The results showed that flavonoid extracts from Brassica nigra is highly active in inhibition than cold equeous extract from Euphorbia prostrata, the inhibitory effect appear to be at a concentration of (25) mg/ml for the flavonoids extract and there is an increase in diameter of inhibition zones with the increase of conc. While the cold equeous extract at (75) mg/ml conc seem to be active on growth at Staphylococcus aureus only. MIC values were determine to be at (50,70) mg/ml for flavonoid extract on Staphylococcus aureus and Escherichia coli respectively and (80,90) mg/ml for cold equeous extract on the same bacteria.The value of LD50 for cold equeous extract was (1383) mg/kg and for flavonoids extract(2500) mg/kg in mice. Also this study proved that the animals infected with Staphylococcus aureus when injected with cold equeous extract of what showed no activity in vivo and died after (2) days of treatment while the animals injected with flavonoids extract gave high activity for Staphylococcus aureusinvivo in (250,300) mg/kg, with clinical symptoms through maintaining the normal values of blood and showed no clinical symptoms after injecting the animals with the flavonoids extract and bacteria, while animal injected with bacteria alone produced changing in blood values and developed clear clinical symptoms ended with the death of animals.
Keyword: Brassica nigra , Euphorbia prostrata L. , invitro , invivo ,Staphylococcus aureus.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.046
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