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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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SEDATIVE EFFECTIVENESS TEST OF EXTRACT LAMTORO LEAF (Leucaena leucocephala)(LAM) De Wit TO MALE MICE

Author: YUSKA NOVIYANTY, HEPIYANSORI, PARWIT
Abstract: Sedative Effectiveness Test from Lamtoro (Leucaena leucocephala) (LAM) de Wit Leaf Extract has been carried out on male mice. Extracts are obtained by maceration and remaseration. The number of groups that conducted the study were 5 groups, Group I was given phenobarbital orally as a positive control / comparison, Group II was given Na. CMC 0.1% orally as a negative control, Group III was given lamtoro leaf extract (Leucaena leucocephala (Lam.) De Wit) at a dose of 5.84 mg / grBB orally as dose 1, Group IV was given leaf extract lamtoro (Leucaena leucocephala (Lam.) De Wit at a dose of 11.68 mg / grBB orally as dose 2, Group V is given a leaf extract of lamtoro (Leucaena leucocephala (Lam.) De Wit) at a dose of 17.52 mg / grBB orally as a dose 3 Note and observe the number of people who fell after 30 minutes above the rotarod.The results obtained after analyzing using the SPSS 16.0 program, namely leaf extract of lamtoro at dose 3 showed a good effect of positive results.
Keyword: Lamtoro Leaf Extract (Leucaena leucocephala) (LAM) de Wit), Sedative Test, Rotarod Method
DOI: https://doi.org/10.31838/ijpr/2019.11.01.044
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