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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of the frequency and the relationship between EBV VCA IgM positive and EBV VCA IgG positive and serum level of 25 (OH) D3 in patients with CIS

Author: ALIREZA NAEINI, MOHAMMAD DARVISHI, SARA KALANTAR, MOHAMMAD AMINIANFAR
Abstract: Multiple sclerosis (MS) is one of the chronic neurological diseases with intermittent relapses and remissions, in which the myelin coating around the peripheral nerves disappear gradually, leading to disrupted conduction of nerve waves. Recent researchers argue that vitamin D deficiency also plays a key role in the development of MS. Nowadays, the use of mineral compounds and vitamins is suggested as one of the treatment options. However, there is still doubt on their effectiveness and value. There are also some debates on the role of various viruses, especially the Epstein Barr virus (EBV) in the development and progression of MS. Thus, the objective of this research was to evaluate the frequency and relationship between EBV VCA IgM positive and EBV VCA IgG positive and serum level of 25 (OH) D3 in patients with CIS. In this descriptive and cross-sectional research, a total of 30 patients with CIS were included into study, serum levels of 25 (OH) D3 and EBV VCA IgM and EBV VCA IgG were determined, they were compared with control group (n=30) and the relationship between them was examined. The CIS group was evaluated by brain and cervical MRI at the beginning of the study and after 3 months, and cases with increased lesions were considered as progression of diseases towards MS. The relationships between these cases and serum levels of 25 (OH) D3 and EBV VCA IgM and EBV VCA IgG were investigated. The results revealed that serum levels of 25 (OH) D3 and EBV VCA IgM and EBV VCA IgG were not significantly correlated (P> 0.05), and their frequencies were not different in the case and control groups (P> 0.05). However, a significant relationship with MRI findings was found (P <0.05). According to the research results and comparing them with other studies conducted in this regard, it is concluded that the serum level of 25 (OH) D3 and positive level of EBV VCA IgG have a significant relationship with the progress of CIS towards MS.
Keyword: CIS, MS, Vitamin D, EBV.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.041
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