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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Co-enzyme Q10 on cerebral hemodynamics in diabetic patients.

Author: ZAHRAA ALHASSANI, AHMED MH AL-MUDHAFAR, LAITH ALDABBAGH
Abstract: Background: diabetic patients are at greater risk to have cerebrovascular accidents like ischemic stroke, vascular dementia and silent lacunar infarctions. They are also deficient in co-enzyme Q10. Previous studies showed that coenzyme Q10 supplement improves macrovascular complications in diabetic patients.we want to find out the effect of co-enzyme Q10 supplements on cerebral hemodynamics in diabetic patients we randomly choose 48 patients with type 2 DM from diabetic center, where they are randomly grouped into two groups. First group: they have supplement with daily dose of 400mg of co-enzyme Q10 orally for 12 weeks and second group: they have placebo supplement for 12 weeks. All patients have transcranial Doppler before and after treatment. Mean flow velocity of first group before treatment was 49.71±7.43 cm/second , while after treatment it increased to 52.92±6.97 cm/second but this was statistically insignificant (p=0.134). Regarding the second group, MFV before treatment was 50.54±7.91 cm/second, and after treatment was 50.58± 7.1 cm/second. The difference between MFV before and after treatment was negligible and insignificant (p=0.984).Resistive index of first group before treatment was 0.66 ±0.086, while after treatment it decreased to 0.61±0.076. This change after treatment was significant (p=0.030). Regarding the second group, RI before treatment was 0.66± 0.074 and it decreased after treatment to 0.64± 0.072. This change in RI of second group was insignificant (p= 0.628). Therefore, CoQ10 may lower cerebral arterial resistance and improve arterial compliance in diabetic patients.
Keyword: co-enzyme Q10, cerebral hemodynamics, type 2 DM, transcranial Doppler INTRODUCTION Cardiovascular
DOI: https://doi.org/10.31838/ijpr/2019.11.01.038
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