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DESIGN AND FORMULATION OF CAPECITABINE CONTROLLED RELEASE TABLET TO TREAT CANCER.
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| Author:
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HARSH VARIA, DR. RAJESH K.S
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| Abstract:
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The purpose of present research work was to design and formulation of capecitabine controlled release dosage form
to achieve a prolonged therapeutic effect with constantly releasing medication over an extended period of time by
administration of a single dose. The present study aims to treat colorectal cancer with improved patient compliance.
The selected drug, capecitabine is designed to release therapeutic concentration over a long period of time and
termed as controlled release dosage form. Capecitabine is readily absorbed from gastrointestinal tract. Hence
controlled release delivers maximum drug in colon lowering dosing frequency. Procured drug was identified as
Capecitabine by solubility study, melting point study, FTIR study and calibration curve development. Controlled
release tablets of capecitabine were prepared using natural polymers like carrageenan gum, locust bean gum and gum
rosin by Wet Granulation Method on basis of trial and error method. All pre-compression parameters like, bulk and
tapped density, angle of repose, carr’s index, hausner’s ratio were calculated and shown passable flow property. All
post-compression parameters like, thickness, hardness, friability, %drug content, in-vitro dissolution study, microbial
limit test and stability study were checked and shown satisfactory results. Controlled release tablets of capecitabine
for colorectal cancer were successfully prepared and evaluated by using natural polymers on drug release.
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| Keyword:
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Controlled release dosage form, Colorectal cancer, Capecitabine, Patient compliance
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.035
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| Download:
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Request For Article
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