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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DESIGN AND FORMULATION OF THERMOREVERSIBLE HYDROGEL CONTAINING CAPECITABINE AS CONTROLLED RELEASE DOSAGE FORM TO TREAT CANCER.

Author: HARSH VARIA, DR. RAJESH K.S
Abstract: The purpose of present research work was to design and formulation of capecitabine controlled release dosage form to achieve a prolonged therapeutic effect with constantly releasing medication over an extended period of time by administration of a single dose. The present study aims to treat colorectal cancer with improved patient compliance. The selected drug, capecitabine is designed to release therapeutic concentration over a long period of time and termed as controlled release dosage form. Capecitabine is readily absorbed from gastrointestinal tract. Hence controlled release delivers maximum drug in colon lowering dosing frequency. Procured drug was identified as Capecitabine by solubility study, melting point study, FT-IR study and calibration curve development. Thermoreversible hydrogel containing capecitabine as a drug, thermoreversible polymer (PF-127) and viscosity enhancing agent (HPMC E-50 LV) were prepared by cold method. The optimization of formulations was performed by 32 factorial design using Design Expert 9.0.4 software. The formulations were evaluated for visual appearance, clarity, gelling capacity, pH, gelling temperature, viscosity, drug content and in-vitro release study, which shown satisfactory results. The results of tests of parenteral formulations indicated that they were free from particulate matters and sterilized completely. The results of stability study indicated that there was no significant change in gelling temperature, viscosity and in-vitro drug release after one month. Thus, thermoreversible hydrogel was successfully prepared and evaluated to provide better prospects for parenteral delivery of capecitabine in treatment of colorectal cancer.
Keyword: Thermoreversible hydrogel, Colorectal cancer, Capecitabine
DOI: https://doi.org/10.31838/ijpr/2019.11.01.034
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