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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DEVELOPMENT AND VALIDATION OF ABSORBANCE CORRECTION METHOD AND FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF GALLIC ACID, ELLAGIC ACID AND CURCUMIN IN POLYHERBAL ANTIDIABETIC DOSAGE FORMS.

Author: MEGHA SHAH, HARSHA PATEL
Abstract: Two simple, rapid, precise, economical and accurate spectrophotometric methods have been developed for simultaneous analysis of Gallic Acid, Ellagic Acid and Curcumin in their combined dosage form. Absorbance Correction methodemploys measurement of marker at particular wavelength where other substances shows no interference.Whilein First order derivative Spectroscopic method,ZCP (Zero cross point) were determined at which measurement of one marker can be done without interference of other markers. Developed methods were validated according to ICH guidelines. The calibration graph follows Beer’s law in the range of 2-20 µg/ml for Gallic Acid, 5-50 µg/ml for Ellagic Acid and 1-10 µg/ml for Curcumin with R square value greater than 0.99. Accuracy of all methods was determined by recovery studies and showed % recovery between 98 to 102%. Intraday and Interday precision was checked for both methods and mean %RSD was found to be less than 2 for both methods. The methods were successfully applied for estimation of Gallic Acid, Ellagic Acid and Curcumin in Polyherbal Antidiabetic formulation.
Keyword: Gallic Acid, Ellagic Acid, Curcumin, First order derivative Spectroscopy, Absorbance correction Method.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.027
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