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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development and In Vitro Evaluation of Tramadol Hydrochloride Oral Controlled Release Ma-trix Tablets

Author: UPLOADED BY-ADMIN, M.M. VARMA , G.L.D.BHAVANI, D.B.RAJU
Abstract: Tramadol hydrochloride was formulated as oral controlled release matrix tablets using hydrophilic polymer, hydroxy propyl methyl cellulose (50cps) along with electrolytes. This work is an attempt for in situ interactions between drug and electrolytes to control the release of highly water soluble drug from oral hydrophilic monolithic system. Electrolytes such as calcium carbonate, magnesium carbonate, sodium bicarbonate and sodium carbonate were used at different concentrations (25 to 100 mg per tablet) in various formulations, while drug & polymer concentration was maintained constant at 1:1 ratio in all the formulations. Direct compression was used for the preparation of matrix tablets. The prepared tablets were evaluated for various physicochemical parameters by official procedures. The in vitro release study of the matrix tablets was carried out in 0.1 N HCl for 2 hours ( pH 1.2) and in pH 6.8 phosphate buffer for the next 10 hours. Electrolytes were used to monitor matrix swelling & gel properties. The results indicated that the drug was released at a controlled rate (over a period of 12 hours) which is due to swelling , matrix stiffening and formation of a uniform gel. Analysis of drug release mechanism from the matrix tablets indicated that the drug release from the matrix tablets was found to be non fickian obeying zero order kinetics.
Keyword: Tramadol HCl, HPMC, Electrolytes, Matrix tablets.
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