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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DYNAMICS OF CENTRAL HEMODYNAMICS PARAMETERS AND CYTOKINE LEVELS IN PATIENTS WITH CORONARY HEART DISEASE AND ARTERIAL HYPERTENSION

Author: T.M. KHOKONOVA, Z.F. KHARAEVA, M.A. UMETOV, S.KH. SIZHAZHEVA, F.M. SHOGENOVA, ZH.KH. SABANCHIEVA, O.KH. GYAURGIEVA, I.A. KHAKUASHEVA
Abstract: We have examined the indexes of aortic central pressure(CPA), arterial stiffness and cytokine levels (levels of proinflammatory cytokine - interleukin-1ß, anti-inflammatory cytokine - interleukin-10, CD40 ligand (CD40L)) were studied in patients with grade 2 and 3 arterial hypertension and coronary heart disease. The results of the study suggest that the increase in the parameters of CPA, vascular stiffness and a decrease in the elasticity of the arterial bed are most noticed among the patients with CHD and cicatricial changes in the myocardium.The highest rates of CD40L were observed among the patients with CHD and IHD CHD with postinfarctioncardiosclerosis (PIC).
Keyword: arterial hypertension, coronary heart disease, central aortal pressure, interleukin -1ß, interleukin-10, CD40L.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.023
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