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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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SYNTHESIS OF TRIAZOLOPHTHALAZINE DERIVATIVES AS ANTI OXIDANT AGENTS

Author: SINGH SMITA, KUMAR NITIN
Abstract: The current research work is aimed to synthesize 3-substituted [1,2,4] triazolo[3,4-a] phthalazine derivatives. 1H NMR, IR and Mass Spectroscopy have been employed for the characterization of synthesized derivatives. Evaluation of antioxidant activity of all the derivatives [1a-1h], is carried out using DPPH model. The title compounds were synthesized by reacting hydrazinyl phthalazin-1(2H)-one with substituted benzoyl chloride followed by refluxing in the presence of DMF, Dioxan and trimethyl amine for 4 hours and were evaluated for antioxidant activity by DPPH Model.The title compounds 1b, 1c, 1e and 1g showed promising free radical scavenging activity when compared to standard drug.3-substituted 1,2,4-triazolo [3,4-a] phthalazine derivatives were synthesized , charecterized and their antioxidant activity evaluated using DPPH free radical scavenging method. Out of all the compound synthesized, only few compounds such as 1b, 1c, 1e and 1g have shown promising free radical scavenging activity when compared to standard drug.
Keyword: Triazole, Phthalazine, Antioxidant activity, DPPH Model.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.020
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