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DESIGN, FORMULATION AND EVALUATION OF NANOSUSPENSION FOR DRUG DELIVERY OF CELECOXIB
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| Author:
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SUNDAR D, DIVYA P, SRIDEVI P, AKHILA K, DHANARAJU M. D.
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| Abstract:
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The present study is aimed to formulate and evaluate celecoxib oral nanosuspension to improve the bioavailability of
the drug with varying concentrations of surfactants and co surfactants. The celecoxib nanosuspension was prepared
by nanoprecipitation method using blend of surfactants Tween 80, Tween 20, PEG 200, Propylene glycol along with
suitable excipients etc. The developed formulations were characterized for particle size and polydispersity index, total
drug content, SEM, Zeta Potential and FTIR. The invitro drug release studies and invitro drug release kinetics were
performed for all formulations. FTIR studies revealed that drug is compatible with the excipients. The particle size and
polydispersity index of optimized formulation was found to be 98nm and the zeta potential was found to be -20 mV
and concluded that the system had sufficient stability. The invitro drug release was found within their acceptable
ranges. The rate of dissolution of best batch was enhanced to 99.22% in 30min. Stability studies proved that
nanosuspensions were more stable with no significant changes in particle size distribution. Thus the formulated oral
nanosuspension of celecoxib offers a superior conventional dosage forms for drug release.
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| Keyword:
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The present study is aimed to formulate and evaluate celecoxib oral nanosuspension to improve the bioavailability of the drug with varying concentrations of surfactants and co surfactants. The celecoxib nanosuspension was prepared by nanoprecipitation method using blend of surfactants Tween 80, Tween 20, PEG 200, Propylene glycol along with suitable excipients etc. The developed formulations were characterized for particle size and polydispersity index, total drug content, SEM, Zeta Potential and FTIR. The invitro drug release studies and invitro drug release kinetics were performed for all formulations. FTIR studies revealed that drug is compatible with the excipients. The particle size and polydispersity index of optimized formulation was found to be 98nm and the zeta potential was found to be -20 mV and concluded that the system had sufficient stability. The invitro drug release was found within their acceptable ranges. The rate of dissolution of best batch was enhanced to 99.22% in 30min. Stability studies proved that nanosuspensions were more stable with no significant changes in particle size distribution. Thus the formulated oral nanosuspension of celecoxib offers a superior conventional dosage forms for drug release.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.013
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| Download:
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