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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

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Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

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Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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DESIGN, FORMULATION AND EVALUATION OF NANOSUSPENSION FOR DRUG DELIVERY OF CELECOXIB

Author: SUNDAR D, DIVYA P, SRIDEVI P, AKHILA K, DHANARAJU M. D.
Abstract: The present study is aimed to formulate and evaluate celecoxib oral nanosuspension to improve the bioavailability of the drug with varying concentrations of surfactants and co surfactants. The celecoxib nanosuspension was prepared by nanoprecipitation method using blend of surfactants Tween 80, Tween 20, PEG 200, Propylene glycol along with suitable excipients etc. The developed formulations were characterized for particle size and polydispersity index, total drug content, SEM, Zeta Potential and FTIR. The invitro drug release studies and invitro drug release kinetics were performed for all formulations. FTIR studies revealed that drug is compatible with the excipients. The particle size and polydispersity index of optimized formulation was found to be 98nm and the zeta potential was found to be -20 mV and concluded that the system had sufficient stability. The invitro drug release was found within their acceptable ranges. The rate of dissolution of best batch was enhanced to 99.22% in 30min. Stability studies proved that nanosuspensions were more stable with no significant changes in particle size distribution. Thus the formulated oral nanosuspension of celecoxib offers a superior conventional dosage forms for drug release.
Keyword: The present study is aimed to formulate and evaluate celecoxib oral nanosuspension to improve the bioavailability of the drug with varying concentrations of surfactants and co surfactants. The celecoxib nanosuspension was prepared by nanoprecipitation method using blend of surfactants Tween 80, Tween 20, PEG 200, Propylene glycol along with suitable excipients etc. The developed formulations were characterized for particle size and polydispersity index, total drug content, SEM, Zeta Potential and FTIR. The invitro drug release studies and invitro drug release kinetics were performed for all formulations. FTIR studies revealed that drug is compatible with the excipients. The particle size and polydispersity index of optimized formulation was found to be 98nm and the zeta potential was found to be -20 mV and concluded that the system had sufficient stability. The invitro drug release was found within their acceptable ranges. The rate of dissolution of best batch was enhanced to 99.22% in 30min. Stability studies proved that nanosuspensions were more stable with no significant changes in particle size distribution. Thus the formulated oral nanosuspension of celecoxib offers a superior conventional dosage forms for drug release.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.013
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477