IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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ENHANCED SOLUBILITY OF ANTIHYPERTENSIVE DRUG USING HYDROPHILIC CARRIER-BASED POTENT SOLID DISPERSION SYSTEMS

Author: KAVITA BAHMANI, YASHPAUL SINGLA
Abstract: Oral bioavailability enhancement of drug having poor water solubility is considered as a very hard task in the formulation development of such drugs. The development of solid dispersions helps to enhance bioavailability of poorly water soluble drugs to overcome the limitations of various approaches such as salt formation, solubilization by cosolvents, and particle size reduction. Studies revealed that drugs in solid dispersion need not necessarily exist in the micronized state. Carvedilol’s ß-adrernergic receptor blocking ability decreases the heart rate, myocardial contractility and myocardial oxygen demand. Carvedilol and its metabolites also prevent OH- radical induced decrease in sarcoplasmic reticulum Ca-ATPase activity. Therefore, carvedilol and its metabolites may be beneficial in the chronic heart failure by preventing free radical damage. Carvedilol belongs to BCS class-II drug having poor water solubility. For the improvement of solubility solid dispersions of carvedilol were prepared using fusion method. Various concentrations of polymers like mannitol and PVPK-30 were used for the preparation o solid dispersions.
Keyword: Solid dispersions, bioavailability, carvedilol (CRL), mannitol, PVP-K30
DOI: https://doi.org/10.31838/ijpr/2019.11.01.011
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0.12
2018CiteScore
 
8th percentile
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477