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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Ocimum on Cervical Intraepithelial Neoplasia (CIN)Pre Cervical Cancer

Author: S.RAHAYU , ROSDIANA NATZIRD, MUH NASRUM MASSIE, SYAHRUL RAUFF, MOCHAMMAD HATTA, MUH HUSNI CANGARA
Abstract: Diethylstilbestrol is a synthetic estrogen hormone which is useful as hormone replacement therapy, but it also can trigger the abnormal cells growth that will develop into cervical cancer. Cervical cancer is associated with invasion and metastasis potential where the gold standard is a histopathological examination. [1][2]Histopathological examination is a method of seeing Cervical Intraepithelial Neoplasia growth. There is no therapy needed at the CIN1 medium, 80% can return to normal. CIN II & III can develop into cancer cells (true cervical cancers precursors). CIN or pre-cancer therapy is more effective and efficient, and also low cost before it develops into malignant cancer cells.Accurate diagnosis and prediction of malignancy are important issues in clinical management, including biomarker identification for CIN diagnosis.CIN screening is an effective method to identify the presence of cancer earlier to decrease the mortality.CIN that has been treated can regrow/recur by some trigger factors such as age, menopause, and surgery. Ocimum has an anti-cancer effect through the caspase-3 induction which stimulates PARF to release cytochrome-c.PARF induces apoptosis in cancer cells through ROS increase. Ocimumhas antioxidant activity, protects cell damage, and acts as a scavenger highly reactive free radicals. The results of the study group who received 100% diethylstilbestrol had Cervical Intraepithelial Neoplasm (CIN).40% at CIN2 and CIN3Stadium, and 20% at CIN1. Chi-square test results showed that there was a significant effect between the administration of diethylstilbestrol and the occurrence of CIN in p-value <0.05. Then, there was no significant effect between the administration of Ocimum extract and CIN stadium withp-value > 0.05.
Keyword: Pre, Cervical Cancer, Diethylstilbestrol, CIN, Ocimum, Perinatal, Wistar Rat, Invivo
DOI: https://doi.org/10.31838/ijpr/2019.11.01.007
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