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Effect of Ocimum on Cervical Intraepithelial Neoplasia (CIN)Pre Cervical Cancer
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| Author:
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S.RAHAYU , ROSDIANA NATZIRD, MUH NASRUM MASSIE, SYAHRUL RAUFF, MOCHAMMAD HATTA, MUH HUSNI CANGARA
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| Abstract:
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Diethylstilbestrol is a synthetic estrogen hormone which is useful as hormone replacement therapy, but it also can
trigger the abnormal cells growth that will develop into cervical cancer. Cervical cancer is associated with invasion
and metastasis potential where the gold standard is a histopathological examination. [1][2]Histopathological
examination is a method of seeing Cervical Intraepithelial Neoplasia growth. There is no therapy needed at the CIN1
medium, 80% can return to normal. CIN II & III can develop into cancer cells (true cervical cancers precursors).
CIN or pre-cancer therapy is more effective and efficient, and also low cost before it develops into malignant
cancer cells.Accurate diagnosis and prediction of malignancy are important issues in clinical management, including
biomarker identification for CIN diagnosis.CIN screening is an effective method to identify the presence of cancer
earlier to decrease the mortality.CIN that has been treated can regrow/recur by some trigger factors such as age,
menopause, and surgery. Ocimum has an anti-cancer effect through the caspase-3 induction which stimulates PARF
to release cytochrome-c.PARF induces apoptosis in cancer cells through ROS increase. Ocimumhas antioxidant
activity, protects cell damage, and acts as a scavenger highly reactive free radicals. The results of the study group who
received 100% diethylstilbestrol had Cervical Intraepithelial Neoplasm (CIN).40% at CIN2 and CIN3Stadium, and
20% at CIN1. Chi-square test results showed that there was a significant effect between the administration of
diethylstilbestrol and the occurrence of CIN in p-value <0.05. Then, there was no significant effect between the
administration of Ocimum extract and CIN stadium withp-value > 0.05.
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| Keyword:
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Pre, Cervical Cancer, Diethylstilbestrol, CIN, Ocimum, Perinatal, Wistar Rat, Invivo
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.007
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| Download:
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