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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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THE CORRELATION OF SERUM HOMOCYSTEIN AND PYRIDOXINE LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Author: PERTIWI DIAN, YASWIR RISMAWATI, YANNI MEFRI
Abstract: Cardiovascular disease is the leading cause of death worldwide. Acute myocardial infarction (AMI) is one of five main manifestations of coronary heart disease and is the leading cause of death in Indonesia. One of several risk factors for the development of acute myocardial infarction is the elevated homocysteine level in the blood. Homocysteine metabolism is affected by pyridoxine as the cofactor. This study aimed to determine the correlation of serum homocysteine and pyridoxine levels in AMI patients. The design of this study was cross-sectional design with samples of 25 randomly selected AMI patients. This study was conducted from August to November 2016 in the Biomedical Laboratory of Faculty of Medicine, Andalas University. The levels of homocysteine and pyridoxine were measured by using ELISA method. Data were analyzed by using Pearson correlation test. The mean result of homocysteine level was 23,17 ± 9,2 nmol/mL, dan the mean level of pyridoxine was 128,44 ± 34,02 pmol/L. There was a significant relationship between the level of homocysteine and the level of pyridoxine (r = -0,530 p=0,006).There was a significant relationship between the level of homocysteine and the level of pyridoxine in patients with acute myocardiCardiovascular disease is the leading cause of death worldwide. Acute myocardial infarction (AMI) is one of five main manifestations of coronary heart disease and is the leading cause of death in Indonesia. One of several risk factors for the development of acute myocardial infarction is the elevated homocysteine level in the blood. Homocysteine metabolism is affected by pyridoxine as the cofactor. This study aimed to determine the correlation of serum homocysteine and pyridoxine levels in AMI patients. The design of this study was cross-sectional design with samples of 25 randomly selected AMI patients. This study was conducted from August to November 2016 in the Biomedical Laboratory of Faculty of Medicine, Andalas University. The levels of homocysteine and pyridoxine were measured by using ELISA method. Data were analyzed by using Pearson correlation test. The mean result of homocysteine level was 23,17 ± 9,2 nmol/mL, dan the mean level of pyridoxine was 128,44 ± 34,02 pmol/L. There was a significant relationship between the level of homocysteine and the level of pyridoxine (r = -0,530 p=0,006).There was a significant relationship between the level of homocysteine and the level of pyridoxine in patients with acute myocardial infarction.al infarction.
Keyword: myocardial infarction, homocystein, pyridoxine level
DOI: https://doi.org/10.31838/ijpr/2019.11.01.006
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