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Formulation and Evaluation of Tablets of Micronized Glibenclamide (Glyburide) in Industrial Set-Up
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| Author:
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UPLOADED BY-ADMIN, S. S. MUDGAL, S. JAYAPRAKASH, M. NAGRAJAN, S. S. PANCHOLI
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| Abstract:
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Up to 3 fold increase in dissolution of glibenclamide from the tablet dosage form could be achieved by
employing micronized drug. Milling was done with Cadmill and Fluid Energy Mill (FEM) for different number
of cycles. Percentage of fines was found to be highest with FEM-3 cycle. A significant difference in dissolution
profile was observed for formulations prepared using different batches of unmicronized and micronized
glibenclamide. Formulation F8 showed highest % dissolution (90.27%) in 30 min. as compared to marketed
brands X (Daonil-5mg from M/s Aventis Pharma) and Y (Euglucon-5mg from M/s Nicholas) (36.85% and
39.44%). Results indicate that mechanical method of micronization for glibenclamide by Fluid Energy Mill
(FEM) was most efficient and cost effective way of achieving particle size reduction and formulation made from
it showed
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| Keyword:
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glibenclamide, dissolution, micronization.
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| DOI:
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