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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In vivo Hepatoprotective Effects on Acacia sinuata (Lour.) Pods in Paracetamol Induced Hepatic Damage in Albino Rats

Author: SARALA ARUMUGAM, MADHU.S
Abstract: The present study aims to investigate the hepatoprotective activity of the aqueous ethanolic extract of Acacia sinuata (Lour.) pods against Paracetamol induced hepatotoxicity in albino rats. Two different doses of Acacia sinuata (Lour.) pods extracts were administered orally for 7 days. The hepatoprotective activity was studied in liver by measuring the parameters like serum levels of Glutamic Oxaloacetate Transaminase (SGOT), Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Total Bilirubin, Total Protein and histopathological changes in liver of different groups of animals were observed. Aqueous ethanolic extract of Acacia sinuata (Lour.) pods has reduced the serum levels of SGOT, SGPT, ALP, Total Bilirubin and elevated the Total Proteins in comparison with Silymarin. The protective effect of the extracts on Paracetamol induced hepatic damage was confirmed by histopathological examination of the liver. The results were strongly supports the protective effect on aqueous ethanolic extract of Acacia sinuata (Lour.) pods against acute liver injury.
Keyword: Hepatoprotective, Paracetamol, Acacia sinuata, Silymarin, Histopathology.
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