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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antimicrobial metabolite producing Streptomyces from the fertile soil of Gujarat active against multidrug resistant clinical pathogen

Author: BINA AGHERA, SAISIVAM SRINIVASAN
Abstract: Pathogenic organisms are acquiring resistance worldwide against existing antibiotics due to the indiscriminate use and associated toxicities leading to the necessity of new antimicrobial substances from natural resources. As soil is one of the potential resources and most of the fertile land soil of Gujarat has not been explored so far, the present work was undertaken to find the suitable antimicrobial producing Streptomyces active against multidrug resistant clinical strains. Streak plate purified soil isolates were tested against test strains of MTCC, Chandigarh by cross streak technique. The potential ones were subjected to shake flask fermentation using suitable media and supernatants were tested against the multidrug resistant clinical strains. The soil isolate GSB11 was found to be more active against Klebsiella species (KPR-45) which was found to be resistant to most of the commonly used antibiotics. Hence, efforts were made to identify and characterize GSB11 based on physiological, biochemical parameters including 16s ribosomal analysis which confirmed that GSB11 is a type strain of Streptomyces enissocaesilis. Active metabolite got extracted in ethyl acetate from shake flask fermented broth culture. Further, ongoing studies will yield a useful characterized metabolite active against various clinical pathogens.
Keyword: Soil Screening, Streptomyces, Fermentation, Antibacterial activity, Multidrug resistant strain
DOI: https://doi.org/10.31838/ijpr/2019.11.01.667
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