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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of antioxidant and anticancer potential of flavonoids from aerial roots of Ficus benghalensis Linn.

Author: JAIN SALONI, JEGAN SAKTHIVEL
Abstract: Ficus benghalensis Linn (Moraceae) is a traditional herb used for variety of biological conditions. It is used as as astringent, haemostatic, anti-inflammatory, antioxidant and anticancer agent and also in the treatment of diarrhoea, dysentery and in the treatment of skin disorders, ulcers, vaginal disorders, leucorrhoea, menorrhagia and in case of deficient lactation. Considering its medicinal importance, the plant was choosen for isolation of flavonoids from ethyl acetate rich extract of its aerial roots using preparative TLC method. LC-MS analysis of ethyl acetate rich extract and its fractions confirmed the presence of flavonoids. The present study was designed with an aim to study the anticancer and antioxidant potential of flavonoids isolated from the ethyl acetate extract and its preparative TLC fractions. Antioxidant study suggested that ethyl acetate rich extract has a good radical scavenging activity when compared to standard drug curcumin (wherein the IC50 value of ethyl acetate rich extract was found to be 52.186± 2.09µg/ml while that of curcumin for which the IC50 value was found to be 3.02±0.29µg/ml). Cytotoxity studies on preparative TLC fractions suggested that the ethyl acetate rich extract and its preparative TLC fractions exhibited anticancer activity on A549 cell line (Lung cancer cell line), MDA-MB-231 cell line (Breast cancer cell line), Hela cell line (cervical cancer cell line) with IC50 values comparable to doxorubicin used as standard drug.
Keyword: Ficus benghalensis Linn, Ethyl acetate rich extract, Cytotoxicity, antioxidant, isolation.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.006
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