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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

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Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

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Crystal structure analysis of N-[(perhydrocyclopenta [c] pyrrol-2-yl) aminocarbonyl]-p-toluenesulfonamide: an oral hypoglycemic agent

Author: RANJANA SHARMA, R. K. TIWARI, DIXIT PRASHER
Abstract: The title compound, gliclazide is a second generation anti-diabetic medicine and belongs to the class of oral hypoglycemic sulfonylurea. The crystal and molecular structure analysis of gliclazide were carried out by operating single X-ray diffraction technique for single crystal. It was observed that gliclazide crystallizes in the monoclinic P21/n space group with unit cell dimensions a = 10.804(5) ?, b = 14.309(5) ?, c = 10.989(5) ?, ß = 106.995(5)0, V= 1624.7(12) Å3, and Z=4; calculated density is 1.322 Mg m-3. The value for structure factor was 688 and final R = 0.0405 for 2851 unique reflections. The average bond distance of C-H and N-C types were 0.96(1) ? and 1.3758 ?, respectively. The mean C-Caromatic bond length in p-toluenesulfonyl component of gliclazide structure was 1.374 (3) Å, showing good match with the standard C-Caromatic bond length of 1.40 Å. Both the fused five membered cyclopentane and pyrrol rings of gliclazide were found to exist in a envelop conformation.
Keyword: gliclazide; anti-diabetic drug; crystal structure; x-ray diffraction.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.004
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477