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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Tadalafil mitigate experimental liver IschemiaReperfusion Injury in Rats via anti-oxidant, antiinflammatory and anti-apoptotic action

Author: GOMAA MOSTAFA-HEDEAB, HANYELHADY, EL-SHAYMAA EL-NAHASS, DINA SABRY
Abstract: liver ischemia reperfusion injury (IRI) represent the major causative agent of liver dysfunction following hepatectomy and liver transplantation. Reperfusion-induced liver damage is more serious than that occurred by ischemia itself. Tadalafil is a phosphodiesterase inhibitor has been used for treating essential or hypoxia-incited pulmonary hypertension in grown-ups and youngsters. Aim is to study the effect of tadalafil on IRI induced experimentally in rats. Wister Rats weighing 140–250g were classified into four groups twelve rats each; Group I: received no treatment or any surgical procedure. Group II: subjected to partial IRI only, without treatment. Group III: received Tadalafil 5 mg/kg/d orally for one week then underwent IRI. Group IV: received Tadalafil 5 mg/kg/d orally for two weeks then underwent IRI. At the end of the experiments; serum ALT, AST, Alkaline phosphatase (ALP) was estimated. The liver of each rat was taken, half for histopathological study and other half for estimation of Liver malondialdehyde (MDA), Catalase, Liver reduced glutathione (GSH), superoxide dismutase (SOD), Hemoxygenase-1 (HO-1), IL6, IL-1b, TNF-a, iNOS, eNOS and Bcl-2. Its compared to normal group; IRI significantly elevates AST, ALT and ALP, MD, TNF-a, IL6, IL-1B; while significantly decrease the HO1, BCL2. Oral administration of Tadalafil significantly decreased AST, ALT and ALP compared to IRI non-treated group, significantly increased the liver MD, TNF-a, IL6, IL-1B expression and significantly decrease the liver expression of HO1, BCL2. tadalafil can attenuate IRinduced liver injury via its anti-oxidants, anti-inflammatory and anti-apoptotic action.
Keyword: liver, reperfusion, tadalafil.
DOI: https://doi.org/10.31838/ijpr/2019.11.01.001
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