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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Review on Stomach Specific Floating In-situ Gel

Author: HEMENDRASINH RATHOD, JITENDRA SINGH YADAV
Abstract: Oral drug delivery is one of the simplest route of delivery of drugs for systemic and local effect. Liquid oral dosage forms are more convenient to administer as compared to solid dosage forms but cannot achieve the sustained release effect due to less residential time in the GIT. The development of in-situ gel systems has received considerable attention over the past few years as it provides the best way to overcome problems of immediate release and short GI residence of liquids. In-situ gel forming drug delivery systems are principle, capable of releasing drug in a sustained manner maintaining relatively constant plasma profiles. The in-situ gel dosage form is a liquid before administration and after it comes in contact with gastric contents gets converted to gel which floats on gastric contents. In-situ gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and ionic cross linking. This achieves increased residence as well as sustained release. In-situ forming drug delivery systems possess potential advantages like simple manufacturing process, ease of administration, reduced frequency of administration, improved patient compliance and comfort. It can be easily applied to the site of drug absorption where they swell to form a strong gel that is capable of prolonging the residence time of the active substance. In-situ gels are administered by oral, ocular, rectal, vaginal, injectable and intra peritoneal route.
Keyword: Floating in-situ gel, Stomach specific drug delivery, Natural and synthetic polymer
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