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The Efficacy and Side Effects of Dexmedetomidine and Morphine in Patient-controlled Analgesia Method after Coronary Artery Bypass Grafting Surgery
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| Author:
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ABDORASOUL ANVARIPOUR, HOSSEIN ASHKPOUR, MEHRAN MARASHIAN, KAMRAN MIRZAEI, ALIREZA JAHANGIRIFARD
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| Abstract:
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Background: The current study headed to conduct this comparison byusing PCA to find the final effects of both drugs on pain and other common complications among patients who suffered CABG surgery in a ICU in Southwest of Iran.
Methods: Through a randomized clinical trial (RCT) 83 patients, 40-80 years of age, who were suitable candidates for elective CABG surgery enrolled the study. From the patients 42 were in a group of patients who were administered PCA with 100cc saline in addition to 200mcgdexmedetomidine and 4mg of ondansetron at the pace of 0.7 mcg/kg/h while 41experienced 100cc saline, 10mg morphine and 4mg ondansetron by PCA with 0.015 mg/kg/h infusion pace in the first 24 hours after surgery. Systolic, diastolic, mean blood pressure and heart rate were checked every 2 hours for a total time of 14 hours after weaning. Sedation level was checked every 1 hours by the “Ramsay” criteria and weaning was done considering the criteria.
Results: Data showed no statistical differences in the scores of immediately after extubating and 12 and 24 hours later between the groups. Repeated measure test determined an improvement in the severity of pain as time went on similarly for both groups.
Conclusions: As dexmedetomidine had similar effects to morphine on pain and hemodynamic features during first 24 hours of surgery as well as extubating time, sedation level and additional demand for analgesics, it would be a perfect alteration for morphine at least postoperatively. Analysis showed the same frequency of nausea and vomiting in the two groups of the current study.
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| Keyword:
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CABG, Morphine, Dexmedetomidine, PCA, Adverse effects
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| DOI:
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