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Spectrophotometric Determination of phenylephrine hydrochloride drug in the existence of 4- Aminoantipyrine: Statistical Study
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| Author:
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ASEEL ALJEBOREE, ABBAS NOOR ALSHIRIFI
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| Abstract:
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A spectrophotometric sensitive, selective and inexpensive method for the determination ofphenolic drug
phenylephrine hydrochloride. The method depended on the oxidation of phenylephrine hydrochlorideby potassium
ferricyanide and coupling of the oxidized product with reagent 4- aminoantipyrine to give intensely coloredabsorbs
light strongly in the spectral region of 503 nm . Beer’s law was obtained in the concentration range of 5-100mgL-
1.Good linearity (r2=0.9992) Under the optimum condition. calculation the standard error , limit of detection(LOD)
(signal/noise = 3),Limits of Quantitation's, LOQ, Accuracy, and precision (R.S.D., %) better than 1%. Study the Effect
of different parameter : order of addition, nature of the complex,temperature and effect of The concentration and
type base.Results of theanalyses of pure drug and dosage forms by the proposed method are in good agreement with
those of the officialmethod
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| Keyword:
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phenylephrine hydrochloride , phenolic drug ,4- aminoantipyrine , spectrophotometric, Pharmaceuticals.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.04.103
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| Download:
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