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Effect of progestogen supplementation early in pregnancy With postdate labour and failure of labor induction among them
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| Author:
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DR. ABDUL, DR. SHYAMAA ABD HASSAN, DR. REEM ALI HADDAD
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| Abstract:
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In obstetrics field, progesterone is used for too many indications like: pregnancy support in IVF cycles (12), treatment of threatened abortion (13), or in the prevention of recurrent abortion (14), though results showed no evidence to support routine use in the last two indications. Several observations have been made in clinical practice that patients receiving progesterone (usually synthetic form called progestogen) early in pregnancy for any of the abovementioned indications usually fail to have spontaneous labor at 40 weeks ( due date of delivery), a time considered to be the starting point for initiation of management of the possible postterm labor with all its inherent complications (2); observations have also been made that supplemented pregnants show failure of labor induction trials at 41 weeks and hence higher caesarian delivery rates with its complications. No previous studies ( regional or global) have been made searching the existence of this relationship. In our study cohort design was implemented on 95 patients searching for the role of progesterone supplementation early in pregnancy in predisposing to the above obstetrical complications. Results of our study proved that this supplementation is risky for prolongation of pregnancy beyond 40 weeks ( RR: 2.611, df: 1, P value: 0.117), as well as failure to induce labour among them ( RR: 1.875, Fisher exact: 0.424, P value: 0.545). In view results we recommend searching the effect on a larger study sample, but in the meanwhile restriction of widened use of supplement prescription among pregnants is to be considered.
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| Keyword:
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progestogen,
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.04.060
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| Download:
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